Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate

Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes enable these metal-based drugs to reach biological targets. Palladium(II) gold(III) complexes, due its structural similarity platinum(II)compounds, be competitive candidates for implementing developing new pharmacological agents. Herein, novel complex triammonium N-carboxyiminodiacetate as ligand has been synthesized characterized by elemental analysis, molar conductivity measurements, FT-IR 1H 13C NMR spectroscopy. The proposed structure was examined compared analogue palladium(II) zinc(II) density functional theory (B3LYP/def2tzvp). Additionally, DNA-binding studies UV/Vis-spectrometer well ethidium-bromide (EB) bovine serum albumin (BSA) quenching spectrofluorometer were performed gold(III), dithiocarbamate complexes. investigated showed a affinity calf thymus DNA (CT-DNA) BSA, higher BSA. exhibited 5-fold stronger binding in comparison zinc(II), but no significantly than complex. Furthermore, demonstrated similar toward BSA interactions are